One woman in eight either has or will develop breast cancer in her lifetime. The earlier breast cancer is detected, the better the chances that therapy will be successful. If detected early, the five-year survival rate exceeds 95%. However, prevention is most important. It is widely accepted that synthetic progestins, such as medroxyprogesterone, increase the risk of breast cancer, but that micronized, natural progesterone does not. In fact, it has been found in recent studies to help prevent breast cancer. It does this by inducing "differentiation" among breast tissue cells and promoting apoptosis ( cell death) , as well as exhibiting a strong antiproliferative effect on at least two breast cancer cell lines.*

There have also been recent studies indicating that Vitamin D may play a role in breast cancer prevention and survival. These studies reported an inverse relation between Vitamin D intake and the risk of breast cancer, along with improvements in survival after a diagnosis of breast cancer in women with higher levels of Vitamin D. Up to 75% of breast cancer patients have been found to be deficient in Vitamin D.  Vitamin D3 (calcitriol) inhibits the growth and induces the differentiation of many malignant cells including breast cancer cells. It does this by inducing cell cycle arrest and stimulating apoptosis. It also inhibits invasion, metastisis and tumor angiogenesis in experimental models of breast cancer.  Breast cancer survivors may derive additional, non-cancer-related benefits from adequate Vitamin D levels, including improvements in bone mineral density, quality of life, and mood. **

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*Ann Clin Lab Sci 1998;28:360-369

** www.ncbi.nlm.gov/pubmed/20156557